KMID : 0370220080520010085
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Yakhak Hoeji 2008 Volume.52 No. 1 p.85 ~ p.91
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Inhibitory Activity of 8-Aminowogonin Analogues Against Prostaglandin E©üProduction
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Jang Jin-Hee
Shin Kwan-Seog Kim Hyun-Pyo Park Hae-Il
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Abstract
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8-Acyl and 8-sulfonylamidowogonin analogues were synthesized as potential anti-inflammatory agents. Nitration of 5,7-dihydroxyflavone (chrysin) followed by methylation of phenol groups and reduction of nitro group yielded 8-aminowogonin analogues. Acylation and sufonylation of 8-aminowogonin followed by demethylation reactions gave the title compunds. The synthesized wogonin analogues showed much reduced inhibitory activity on prostaglandin E©ü(PGE©ü) production.
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KEYWORD
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Wogonin, 8-acylamido, 8-arylsulfonamido, Prostaglandin $E_2\, (PGE_2)$, Production
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